Amphotericin B is a polyene antifungal which is not absorbed orally but which can be given parenterally for the treatment of severe systemic fungal infections.
Amphotericin B also has activity against Trichomonas, Entamoeba, Naegleria, Leishmania and trypanosomes.
Griseofulvin or terbinafine can be used in the treatment of dermatophyte nail infections.